Analytical Differentiation Of 1 Alkyl 3 - 3661 Words

Draft 5 Analytical Differentiation of 1-Alkyl-3-acylindoles and 1-Acyl-3-alkylindoles: Isomeric Synthetic Cannabinoids Jack DeRuiter, Forrest T. Smith, Karim Abdel-Hay and C. Randall Clark* Department of Drug Discovery and Development Harrison School of Pharmacy Auburn University Auburn, AL 36849 * Corresponding Author: Professor C. Randall Clark, Ph. D. clarkcr@auburn.edu phone 334-844-8326 fax 334-844-8331 Abstract The 1-alkyl-3-acylindoles and the inverse regioisomeric 1-acyl-3-alkylindoles can be prepared directly from a common set of precursor materials and using similar synthetic strategies. The EI mass spectra for these isomers show a number of unique ions which allow for the differentiation of the 1-alkyl-3-acylindole compounds from the inverse regioisomeric 1-acyl-3-alkylindoles. The base peak at m/z 214 in the 1-n-pentyl-3-benzoylindole represents the M-77 cation fragment resulting from the loss of the phenyl group and this ion is not observed in the inverse isomer. The 1-benzoyl-3-n-pentylindole inverse regioisomer shows a base peak at m/z 105 for the benzoyl cation. Thus, these two base peaks are the result of fragmentation initiated at the carbonyl-oxygen for both isomers. The 1-pentyl-3-benzoylindole is characterized by the strong intensity carbonyl band at 1703 cm-1 while the amide carbonyl appears as a strong band of equal intensity at 1681 cm-1 in the 1-benzoyl-3-pentyl regioisom er. 1. Introduction A number of synthetic cannabinoids includingShow MoreRelatedDifferentiation Of Cyclic Tertiary Amine Cathinone Derivatives4413 Words   |  18 Pages Differentiation of Cyclic Tertiary Amine Cathinone Derivatives by Product Ion Electron Ionization Mass Spectrometry Younis Abiedalla1, 2, Karim Abdel-Hay1, 3, Jack DeRuiter1 and C. Randall Clark1* (1) Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL 36849, USA (2) Department of Medicinal Chemistry, Faculty of Pharmacy, Omar Al-Mukhtar University, El-Beida, Libya (3) Dept. of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, AlexandriaRead MoreEssay The Chemistry and Effects of Benzodiazepines (BZD)2645 Words   |  11 PagesBZD abusers in forensic settings was demonstrated and the most important analytical techniques used for screening and measurement of BZD in forensic laboratory were described. In this project, selected gas chromatography-mass spectrometry (GC-MS) and Liquid Chromatography- Tandem Mass Spectrometry (LC-MS/MS) spectra of diazepam (MS lab, Prof M. Abdel-Hamid) for confirmation and quantitation of diazepam are presented. 1. Introduction: BZD are a group of chemically synthetic compounds that